Application of permanganate in the oxidation of micropollutants: a mini review
Xiaohong GUAN, Di HE, Jun MA, Guanghao CHEN
《环境科学与工程前沿（英文）》
2010年
第4卷
第4期
页码 405-413
doi:
10.1007/s11783-010-0252-8
摘要：
As a green oxidant, permanganate has received considerable attention for the removal of micropollutants in drinking water treatment. To provide a better understanding of the oxidation of organic micropollutants with permanganate, the oxidation kinetics of 32 micropollutants were compiled. The pollutants include algal toxins, endocrine disrupting chemicals (EDCs), and pharmaceuticals. The oxidation kinetics of micropollutants by permanganate were found to be first order with respect to both contaminant and permanganate concentrations from which second-order rate constants ( ″) were obtained. Permanganate oxidized the heterocyclic aromatics with vinyl moiety (i.e., microcystins, carbamazepine, and dichlorvos) by the addition of double bonds. For the polycyclic aromatic hydrocarbons (PAHs) with alkyl groups, permanganate attacked the benzylic C-H through abstraction of hydrogen. The mechanism for the oxidation of phenolic EDCs by permanganate was a single electron transfer and aromatic ring cleavage. The presence of background matrices could enhance the oxidation of some phenolic EDCs by permanganate, including phenol, chlorinated phenols, bisphenol A, and trichlosan. The toxicity of dichlorvos solution increased after permanganate oxidation, and the estrogenic activity of bisphnol A/estrone increased significantly at the beginning of permanganate oxidation. Therefore, the toxicity of degradation products or intermediates should be determined in the permanganate oxidation processes to better evaluate the applicability of permanganate. The influence of background ions on the permanganate oxidation process is far from clear and should be elucidated in the future studies to better predict the performance of permanganate oxidation of micropollutants. Moreover, methods should be employed to catalyze the permanganate oxidation process to achieve better removal of micropollutants.
关键词：
pharmaceuticals
endocrine disrupting chemicals (EDCs)
algal toxins
permanganate
oxidation
Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent
Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE
《环境科学与工程前沿（英文）》
2014年
第8卷
第1期
页码 18-26
doi:
10.1007/s11783-013-0573-5
摘要：
The purpose of this study was to give a worldwide overview of the concentrations of typical estrogenic endocrine disrupting chemicals (EDCs) in the effluent of sewage plants and then compare the concentration distribution of the estrogenic EDCs in ten countries based on the survey data of the estrogenic EDCs research. The concentrations of three main categories (totally eight kinds) of estrogenic EDCs including steroidal estrogens (estrone (E1), estradiol (E2), estriol (E3) and 17α-ethynylestradiol (EE2)), phenolic compounds (nonylphenol (NP) and bisphenol A (BPA)) and phthalate esters (dibutyl phthalate (DBP) and dibutyl phthalate (2-ethylhexyl) phthalate (DEHP)) in the effluents of sewage plants reported in major international journals over the past decade were collected. The statistics showed that the concentration distributions of eight kinds of EDCs were in the range of ng·L to μg·L . The concentrations of steroidal estrogens mainly ranged within 50.00 ng·L , and the median concentrations of E1, E2, E3 and EE2 were 11.00, 3.68, 4.90 and 1.00 ng·L , respectively. Phenolic compounds and phthalate esters were found at μg·L level (some individual values were at the high level of 40.00 μg·L ). The median concentrations of BPA, NP, DBP and DEHP were 0.06, 0.55, 0.07 and 0.88 μg·L , respectively. The concentrations of phenolic compounds and phthalate esters in the effluents were higher than that of steroids estrogens. The analysis of the concentration in various ten countries showed that steroids estrogens, phenolic compounds and phthalate esters in sewage plant effluents were detected with high concentration in Canada, Spain and China, respectively.
关键词：
estrogenic endocrine disrupting chemicals
concentration distribution
sewage plant
In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water
Kaifeng RAO, Na LI, Mei MA, Zijian WANG
《环境科学与工程前沿（英文）》
2014年
第8卷
第1期
页码 69-78
doi:
10.1007/s11783-013-0502-7
摘要：
Effluents from wastewater treatment plant (WWTP) have been reported to have a broad spectrum of endocrine disrupting compounds (EDCs). The majority of studies have focused on the occurrence of estrogenic activity, while ignoring nuclear hormone receptors (NRs) pathways. In the present study, a battery of in vitro yeast bioassays and a cell bioassay, including antagonistic and agonistic effects on estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR), estrogen-related receptor (ERR) and aryl hydrocarbon receptor (AHR), were conducted to evaluate the removal efficiencies of EDCs by different treatment processes of a WWTP located in Beijing. Estrogenic, anti-estrogenic, anti- androgenic, anti-progesteronic, anti-ERR and the activation of AHR activities were detected in samples from all treatment processes and the receiving water. The concentration of estrogenic contaminants with estradiol (E ) equivalent concentrations ranged from 0.82 × 10 to 3.54 × 10 g E -EQ·L . The concentration of anti-estrogenic contaminants with 4-hydroxytamoxifen (4-OHT) equivalent concentrations ranged from 1.24 × 10 to 2.36 × 10 g 4-OHT-EQ·L . The concentration of anti-androgenic contaminants ranged from 2.21 × 10 to 3.52 × 10 g flutamide-EQ·L . The concentration of anti-progesteronic contaminants ranged from 3.15 × 10 to 2.71 × 10 g RU486-EQ·L . The concentration of anti-ERR contaminants ranged from 7.09 × 10 to 6.50 × 10 g 4-OHT-EQ·L . The concentration of AHR activators ranged from 1.7 × 10 to 3.4 × 10 g TCDD-EQ·L . These processes including secondary clarifier, coagulation, as well as coal and sand filtration could eliminated 67.2% of estrogenic contaminants, 47.0% of anti-estrogenic contaminants, 98.3% of anti-androgenic contaminants, 88.4% of anti-progesteronic contaminants, 65.4% of anti-ERR contaminants and 46.9% of AHR activators. WWTP effluents contain multiple receptor disruptors may have very complex adverse effects on exposed organisms.
关键词：
waste water
in vitro
recombinant yeast assay
ethoxyresorufin-O-deethylase (EROD)
receptor
endocrine
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor
Wenjie Zhu, Binghe Xu
《医学前沿（英文）》
2021年
第15卷
第2期
页码 208-220
doi:
10.1007/s11684-020-0795-4
摘要：
New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.
关键词：
endocrine-resistant
HR+/HER2- advanced breast cancer
randomized clinical trials
meta-analysis
targeted therapy
Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation
XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui
《环境科学与工程前沿（英文）》
2007年
第1卷
第3期
页码 350-356
doi:
10.1007/s11783-007-0060-y
摘要：
The ozone oxidation of endocrine disruptor bisphenol A in drinking water was investigated. A stainless completely mixed reactor was employed to carry out the degradation experiments by means of a batch model. With an initial concentration of 11.0 mg/L, the removal efficiencies of BPA (bisphenol A) could be measured up to 70%, 82%, and 90% when the dosages of ozone were 1, 1.5, and 2 mg/L, respectively. The impacts on BPA degradation under the conditions of different ozone dosages, water background values, BPA initial concentrations, and ozone adding time were analyzed. The results showed that ozone dosage plays a dominant role during the process of BPA degradation, while the impact of the contact time could be ignored. UV wavelength scanning was used to confirm that the by-products were produced, which could be absorbed at UV254. The value of UV254 was observed to have changed during the ozonation process. Based on the change of UV254, it could be concluded that BPA is not completely degraded at low ozone dosage, while shorter adding time of total ozone dosage, high ozone dosage, and improvement of dissolved ozone concentration greatly contribute to the extent of BPA degradation. The effects of applied HO dose in ozone oxidation of BPA were also examined in this study. The O-HO processes proved to have similar effects on the degradation of BPA by ozone oxidation.
关键词：
BPA
scanning
reactor
process
O-HO
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
《环境科学与工程前沿（英文）》
2014年
第8卷
第3期
页码 433-440
doi:
10.1007/s11783-013-0594-0
摘要：
Study on effective disposal and utilization of sewage sludge has recently been the target of growing interest in China. However, potential risks are associated with the use of sludge due to its contamination with toxic organics, heavy metals and pathogenic microorganisms. In this study, a screening assessment was conducted on sewage sludge samples collected from 17 different sewage treatment plants in Beijing, based on a batch of in vitro bioassays, including a set of recombinant gene yeast assays for endocrine disruption, and an ethoxy resorufin-O-deethylase (EROD) assay using H4IIE cells for aryl hydrocarbon receptor (Ah-R) agonistic activities. Our results suggested that moderate levels of estrogen receptor agonistic activities (0.9 ng E2·g to 6.8 ng E2·g , dw), but relative higher androgen receptor antagonistic activities (nd to 45%), progestin receptor antagonistic activities (nd to 80%) and Ah-R agonistic activities (1390 to 6740 pg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)·g , dw) were found in sewage sludge samples. However, there were no significant correlations between the toxic effects of sewage sludge and the sewage treatment processes. In addition, the 17β-estradiol (E2) equivalent quantity (EEQ) level of the sewage sludge was increased after the composting treatment, whereas the 2,3,7,8-tetrachlorodibenzo- -dioxin toxic equivalent quantity (TEQ) level of sewage sludge composted was much lower than that of sewage sludge.
关键词：
sewage sludge
in vitro bioassay
endocrine disruption
dioxin-like effect
标题
作者
时间
类型
操作
Determination and occurrence of endocrine disrupting compounds, pharmaceuticals and personal care products
Yong YU,Laosheng WU
期刊论文
nanochannels of MOF thin-film nanocomposite nanofiltration membranes for efficient removal of hydrophobic endocrinedisrupting compounds
期刊论文
Effect of gastric fluid on adsorption and desorption of endocrine disrupting chemicals on microplastics
期刊论文
Application of permanganate in the oxidation of micropollutants: a mini review
Xiaohong GUAN, Di HE, Jun MA, Guanghao CHEN
期刊论文
Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration
期刊论文
Occurrence of estrogenic endocrine disrupting chemicals concern in sewage plant effluent
Yan SUN, Huang HUANG, Ying SUN, Chao WANG, Xiaolei SHI, Hongying HU, Takashi KAMEYA, Koichi FUJIE
期刊论文
In vitro agonistic and antagonistic endocrine disrupting effects of organic extracts from waste water
Kaifeng RAO, Na LI, Mei MA, Zijian WANG
期刊论文
食品中环境新污染物危害管控研究
陈玲 ,杨潇 ,张琳钰 ,胡海冬 ,王瑾丰 ,吴兵 ,任洪强
期刊论文
The temporal changes of the concentration level of typical toxic organics in the river sediments around Beijing
Qiang Li, Xiong Xu, Yaoyao Fang, Ruiyang Xiao, Donghong Wang, Wenjue Zhong
期刊论文
Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor
Wenjie Zhu, Binghe Xu
期刊论文
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and
期刊论文
Degradation of endocrine disruptor bisphenol A in drinking water by ozone oxidation
XU Bin, GAO Naiyun, RUI Min, WANG Hong, WU Haihui
期刊论文
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
期刊论文
Recent advances in electrochemical decontamination of perfluorinated compounds from water: a review
期刊论文
Effect of co-existing organic compounds on adsorption of perfluorinated compounds onto carbon nanotubes
Shubo DENG,Yue BEI,Xinyu LU,Ziwen DU,Bin WANG,Yujue WANG,Jun HUANG,Gang YU
期刊论文
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